首页> 外国专利> Sandwich assay using the decreasing signal portion of the dose-response curve to measure the analyte, such as a high-concentration assay

Sandwich assay using the decreasing signal portion of the dose-response curve to measure the analyte, such as a high-concentration assay

机译:使用剂量反应曲线的递减信号部分进行夹心测定以测量分析物,例如高浓度测定

摘要

The sandwich lateral flow assay devices, systems, and methods described herein measure the concentration of the analyte of interest in a sample and determine the exact concentration of the analyte in the presence of high concentrations. be able to. The maximum intensity signal is generated when the concentration of the target analyte in the sample is zero. For low concentration analytes, the lateral flow assay described herein produces a signal that is the same as or substantially equivalent to the maximum intensity signal. High-concentration objective analytes produce signals that are less than the maximum intensity signal. The lateral flow assay of the present disclosure solves the drawbacks associated with the hook effect of sandwich-type lateral flow assays by eliminating the phase of the dose-response curve where the signal increases. [Selection diagram] FIG. 6A
机译:本文所述的夹心横向流动测定装置,系统和方法测量样品中目标分析物的浓度,并在存在高浓度时确定分析物的确切浓度。能够。当样品中目标分析物的浓度为零时,将生成最大强度信号。对于低浓度的分析物,本文所述的侧向流动测定法产生的信号与最大强度信号相同或基本相等。高浓度目标分析物产生的信号小于最大强度信号。本公开的侧向流动测定法通过消除信号增加的剂量响应曲线的相位而解决了与夹心式侧向流动测定法的钩效应相关的缺点。 [选择图] 6A

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