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Sandwich assay using the decreasing signal portion of the dose-response curve to measure the analyte, such as a high-concentration assay
Sandwich assay using the decreasing signal portion of the dose-response curve to measure the analyte, such as a high-concentration assay
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机译:使用剂量反应曲线的递减信号部分进行夹心测定以测量分析物,例如高浓度测定
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摘要
The sandwich lateral flow assay devices, systems, and methods described herein measure the concentration of the analyte of interest in a sample and determine the exact concentration of the analyte in the presence of high concentrations. be able to. The maximum intensity signal is generated when the concentration of the target analyte in the sample is zero. For low concentration analytes, the lateral flow assay described herein produces a signal that is the same as or substantially equivalent to the maximum intensity signal. High-concentration objective analytes produce signals that are less than the maximum intensity signal. The lateral flow assay of the present disclosure solves the drawbacks associated with the hook effect of sandwich-type lateral flow assays by eliminating the phase of the dose-response curve where the signal increases. [Selection diagram] FIG. 6A
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