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Sandwich-type assays using decreasing signal portions of dose response curve to measure analytes, including analytes at high concentration
Sandwich-type assays using decreasing signal portions of dose response curve to measure analytes, including analytes at high concentration
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机译:使用剂量响应曲线的递减信号部分的夹心型测定法,以测量分析物,包括高浓度的分析物
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摘要
Sandwich-type lateral flow assay devices, systems, and methods described herein measure concentration of an analyte of interest in a sample, and can determine the precise concentration of the analyte when it is present at high concentrations. A signal of maximum intensity is generated when the concentration of analyte of interest in a sample is zero. For low concentrations of analyte, the lateral flow assays described herein generate signals that are the same as or substantially equivalent to the maximum intensity signal. High concentrations of the analyte of interest generate signals that are less than the maximum intensity signal. Lateral flow assays of the present disclosure solve drawbacks associated with the hook effect of sandwich-type lateral flow assays by eliminating the phase of the dose response curve where signals are increasing.
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