Development of biomarkers in cancer ketone diet therapy

摘要

The present invention provides a method for selecting cancer patients who are effective in ketogenic diet therapy and a method for predicting the effectiveness of ketogenic diet therapy in cancer patients. Regarding serum derived from cancer patients before taking a ketogenic diet, acylcarnitine (12: 0), acylcarnitine (12: 1) -2, acylcarnitine (12: 1) -3, acylcarnitine (14: 1)- 1, acylcarnitine (14: 2) -1, acylcarnitine (14: 2) -2, acylcarnitine (14: 3) -2, acylcarnitine (16: 1), acylcarnitine (16: 2), anandamide, Results of analysis of at least one pre-intake candidate substance selected from the group consisting of heptadecenoic acid, hypotaurine, linoleyl ethanolamide, palmitoleic acid, palmitoylcarnitine, phytosphingosine, quinic acid, uric acid, alanine, citrulline, tryptophan, and lysine And the analysis result is used as an index.