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Methods for optimizing assembly and production of heteromultimeric protein complexes
Methods for optimizing assembly and production of heteromultimeric protein complexes
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机译:优化异源多聚体蛋白复合物组装和生产的方法
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摘要
Methods are provided to improve the expression of protein complexes by tuning the expression levels of each component required for the assembly of the complex. These methods are effective in limiting the expression of the dominant chain and, thus, equilibrating their relative abundance. The methods provided herein lead to a significant increase in productivity and final bispecific yields both in transient expression systems as well as in stably transfected mammalian cells.
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