Enterovirus 71 animal model

摘要

The present invention relates to Enterovirus 71 (EV71), the development of an animal model and screening of candidate anti-EV71 compounds. More specifically, the present invention relates to the discovery that Enterovirus 71 (EV71 ) strains that have been adapted to infect rodent cell lines or cloned derived virus containing mutations in VP1 can cause disease in immuno-competent rodents.