Inhibitor-functionalized ultra-small nanoparticles and methods thereof

摘要

Described herein are novel conjugates containing an inhibitor (eg, a PSMA inhibitor, eg, a gastrin releasing peptide receptor inhibitor) covalently attached to a macromolecule (eg, a nanoparticle, polymer, protein) and a metal chelator. I do. Such conjugates exhibit different properties than the free unbound inhibitor / chelator construct. Described herein are prostate cancer (PC) -targeting nanoparticles (eg, PC-targeting dots (C'dots)) that detect disease and allow more reliable staging of the disease. Is done.