Matrix-assisted laser desorption mass spectrometry for high molecular weight polyoxyethylene derivatives

摘要

In order to obtain signals with higher intensity than in conventional methods of matrix-assisted laser desorption/ionization (MALDI) mass spectrometry for high-molecular-weight polyethylene glycol derivatives, a method of MALDI mass spectrometry is provided in which a mixture of a polyethylene glycol derivative having a molecular weight of 40,000 or higher and a matrix is irradiated with laser light to vaporize the polyethylene glycol derivative together with the matrix and determine the molecular weight thereof. The MALDI mass spectrometry is characterized by using, as the matrix, a lowly polar matrix having a 1-octanol/water partition coefficient (logPow) of 4.1-4.8.