Truncated von Willebrand factor polypeptide for extravascular administration in the treatment or prevention of blood clotting disorders

摘要

The present invention relates to a recombinant polypeptide comprising truncated von Willebrand factor (VWF) for use in the treatment or prevention of a blood coagulation disorder, wherein the treatment or prevention comprises recombinant polypeptide and factor VIII protein (FVIII). ) Is administered extravascularly to a subject having a blood coagulation disorder, wherein the recombinant polypeptide is capable of binding to the FVIII, and the recombinant polypeptide to be administered is directed against the FVIII to be administered. The molar ratio is greater than 50.