首页> 外国专利> Method for producing composition for inducing adipocyte differentiation or regenerating adipose tissue containing exosome derived from stem cell

Method for producing composition for inducing adipocyte differentiation or regenerating adipose tissue containing exosome derived from stem cell

机译:包含脂肪细胞的外来体的诱导脂肪细胞分化或再生脂肪组织的组合物的制造方法

摘要

The present invention relates to a pharmaceutical composition for inducing differentiation into adipocytes and/or regeneration of adipose tissues containing, as an active ingredient, an exosome derived from stem cells differentiating into adipocytes. The exosome shows an excellent expression rate of bioactive factors influencing the differentiation into adipocytes and has the effect of differentiating stem cells into adipocytes. Accordingly, the present invention can be applied as stem cell differentiation inducing agents, injectable preparations for tissue regeneration, fillers for cosmetic purposes, preparations for tissue engineering, etc. Further, the present invention relates to a cosmetic composition for skin whitening, wrinkle improvement and skin regeneration containing, as an active ingredient, an exosome derived from stem cells. The exosome contains genes, proteins, growth factors and the like associated with cell proliferation, differentiation and regeneration of stem cells; is a purified component which does not include antibiotics, serums or harmful factors of a culture solution; and is a cell-derived lipid carrier, and thus, the exosome can be applied to functional cosmetic compositions having skin whitening, wrinkle improvement and skin regeneration functions, and preparations for improving scar for cosmetic purposes, etc.
机译:本发明涉及一种用于诱导分化为脂肪细胞和/或再生脂肪组织的药物组合物,所述药物组合物含有作为活性成分的来源于分化为脂肪细胞的干细胞的外来体。外泌体显示出影响分化为脂肪细胞的生物活性因子的优异表达率,并具有将干细胞分化为脂肪细胞的作用。因此,本发明可用作干细胞分化诱导剂,用于组织再生的注射制剂,用于化妆品目的的填充剂,用于组织工程的制剂等。此外,本发明涉及用于皮肤增白,改善皱纹和皮肤的化妆品组合物。皮肤再生含有有效成分干细胞衍生的外来体。外泌体包含与干细胞的细胞增殖,分化和再生有关的基因,蛋白质,生长因子等。是纯化成分,不包含抗生素,血清或培养液的有害因素;该外泌体可用于具有皮肤增白,改善皱纹和皮肤再生功能的功能性化妆品组合物,以及用于美容目的的改善疤痕的制剂等。

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