Adipose Tissue Derived Stem Cells for Regeneration and Differentiation into Insulin-Producing Cells

摘要

Stem cells are considered an ideal tool for the supply of insulin-producing cells or repairing damaged pancreatic tissues to treat ndiabetes mellitus, with the possibility of unlimited sources. This cell population includes embryonic, adult bone marrow, pancreatic stem ncells, extra pancreatic (such as hepatic cells) and adipose-derived stem cells. Multipotent adipose tissue-derived stem cells (ADSCs) are nabundant in the human body, and thus are an ideal donor source for autologous transplantation to generate insulin-producing cells. nMoreover these cells are better sources than bone marrow stem cells (BMSCs) for clinical applications, owing to minimal invasive pro-ncedures, high proliferation and multi-differentiation potential. Human adipose tissue-derived stem cells (hADSCs) may thus provide an nalternative stem cell source, replacing BM-MSCs or embryonic stem cells (ESCs) for future clinical use in diabetes mellitus treatment.