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Periodontal pathogen plasma or serum antibody titer test kit
Periodontal pathogen plasma or serum antibody titer test kit
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机译:牙周病原体血浆或血清抗体滴度测试试剂盒
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摘要
The object of the present invention is to provide: a test kit for an antibody titer or an antibody against a periodontal disease-causing bacterium in a blood sample, which enables the testing on a periodontal disease in patients having a wide scope of immunotypes with high accuracy and can be treated by an automated device at a high speed; a periodontal disease-causing bacterium antigen protein which can be suitably used in the kit; a method for testing an antibody titer or the presence of an antibody in a blood sample using the kit; and a kit for typing strains of Porphyromonas gingivalis. The present invention discloses: a test kit comprising a set of polypeptides respectively having the acid sequences represented by SEQ ID NOs: 1, 3, 9, 15, 19, 31, 41, 43, 63, 65 and 67; a modified polypeptide having the amino acid sequence represented by SEQ ID NO: 67; and a method for determining an antibody titer or the presence of an antibody against a periodontal disease-causing bacterium in a blood sample separated from a human body, comprising bringing the blood sample into contact with the above-mentioned set of polypeptides.
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机译:本发明的目的是提供:血液样品中的针对牙周疾病致病菌的抗体效价或抗体的测试试剂盒,其能够对免疫范围广,免疫力高的患者进行牙周疾病的测试。精度高,可以通过自动化设备进行高速处理;可以在试剂盒中适当使用的引起牙周疾病的细菌抗原蛋白;使用试剂盒测试血液中抗体滴度或抗体的存在的方法;以及用于打字牙龈卟啉单胞菌菌株的试剂盒。本发明公开了一种测试试剂盒,其包含分别具有由SEQ ID NO:1、3、9、15、19、31、41、43、63、65和67表示的酸序列的一组多肽;具有氨基酸序列SEQ ID NO:67所示的修饰多肽;以及在与人体分离的血液样品中测定针对引起牙周疾病的细菌的抗体效价或抗体的存在的方法,其包括使血液样品与上述多肽组接触。
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