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Suppression of errors in sequencing DNA fragments using redundant reads with a specific molecular index (UMI)
Suppression of errors in sequencing DNA fragments using redundant reads with a specific molecular index (UMI)
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机译:使用具有特定分子索引(UMI)的冗余读取来抑制DNA片段测序中的错误
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摘要
The disclosed embodiments concern methods, apparatus, systems and computer program products for determining sequences of interest using unique molecular index (UMI) sequences that are uniquely associable with individual polynucleotide fragments, including sequences with low allele frequencies and long sequence length. In some implementations, the UMIs include both physical UMIs and virtual UMIs. In some implementations, the unique molecular index sequences include non-random sequences. System, apparatus, and computer program products are also provided for determining a sequence of interest implementing the methods disclosed.
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