Fluorine-substituted 2-arylbenzoheterocyclic compounds containing a chiral side chain substituent having affinity for Aβ plaque, production method and application thereof

摘要

A fluorinated 2-arylbenzo heterocyclic compound with high affinity to A² plaques and containing a chiral side chain substituent, has a general formula (I) as follows: wherein X is N; Y is S or O; Z is N or CH; R 1 is a 5 or 6- substituent and is F is 19 F or 18 F; R 2 is NHCH 3 or N(CH 3 ) 2 . The compound of the present invention has high affinity to A² plaques and can be used to make appropriate radioactive nuclide labeling probes for early diagnosis of AD.