SCREENING METHOD USING, AS INDEX, EXPRESSION LEVEL OF OCCULUDIN GENE, CLAUDIN GENE AND ZO-1 GENE UNDER HYPOXIC CONDITIONS, AGENT FOR INHIBITING DECREASE IN EXPRESSION LEVEL OF CLAUDIN GENE, AGENT FOR INHIBITING DETERIORATION OF FUNCTIONS OF CELL ADHESION DEVICE, AND AGENT FOR IMPROVING OR PREVENTING DETERIORATION OF SKIN BARRIER FUNCTIONS

摘要

To provide a new technique for screening a component having the effects of improving or preventing the skin aging phenomenon, particularly, deterioration of skin barrier functions caused by aging.SOLUTION: The present invention uses, as indexes, the effects of inhibiting a decrease in expression levels of occuludin gene, claudin gene, zo-1 gene and cadherin gene in cells cultured under hypoxic conditions.SELECTED DRAWING: Figure 1