Toxicity of Experimental Jet Fuel System Ice-Inhibiting Agents: 2. Gene Expression Response Profiling

摘要

The potential toxicities of compounds to replace current US Air Force operational chemicals is of particular interest. A group of jet fuel system ice-inhibiting agent alternatives currently being evaluated for performance include derivations of 1 ,3-dioxolane%-methanols and 1 ,3-dioxanes. The experiments presented here were performed in support of Air Force Research Laboratory Materials Directorate research on FSII alternatives. Our initial approach to evaluating potential toxicity utilized primary rat hepatocyte cultures and gene profiling assays for assessing acute toxicity. The we of gene profiling assays, as presented here assist in developing patterns of toxicity and biological effects for chemicals or groups of chemicals. These profiles can then be wed assist in the selection of appropriate operational chemicals. Here, the potential toxicities of a group of FSIIs is assessed.