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Spinosad heterologous expression strain and method for construction and use thereof
Spinosad heterologous expression strain and method for construction and use thereof
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机译:棘孢异源表达菌株及其构建和应用方法
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摘要
The invention provides a construction method of spinosad heterologous expression strain, a spinosad heterologous expression strain obtained by the method and use thereof in preparing spinosad. The method utilizes a plurality of homologous recombination to replace the erythromycin synthetic gene cluster of Saccharopolyspora erythraea with the spinosad synthetic gene cluster and the rhamnose synthetic gene cluster, such that the Saccharopolyspora erythraea produces spinosad.
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