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Gene construct encoding mutant thioesterase, mutant thioesterase encoded thereby, transformed host cell containing the gene construct, and method of using them to produce medium-chain fatty acids
Gene construct encoding mutant thioesterase, mutant thioesterase encoded thereby, transformed host cell containing the gene construct, and method of using them to produce medium-chain fatty acids
Unnatural, mutated thioesterases having an amino acid sequence that is at least 80% identical to SEQ ID NO:1 and having substitutions at one or more of amino acid positions I107, R108, L109, S122, M141, E142, Y145, and L146, gene constructs encoding and configured to express the mutated thioesterases in a transformed host cell, and host cells transformed to contain the gene constructs.
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机译:具有与SEQ ID NO:1至少80%相同的氨基酸序列且在一个或多个氨基酸位置I107,R108,L109,S122,M141,E142,Y145和L146上具有取代基的非天然突变硫酯酶,基因构建体编码并配置为在转化的宿主细胞中表达突变的硫酯酶,转化的宿主细胞包含该基因构建体。
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