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Edible vaccines expressed in yeast for preventing and treating infectious diseases, including hepatitis B, in humans

机译：酵母中表达的可食用疫苗，用于预防和治疗人类包括乙型肝炎在内的传染病

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摘要

In the invention described here, the approach is to formulate an edible vaccine based on N-terminal yeast surface display expression platform that producing S.cerevisiae EBY100/pYD5-preS2/S(adw) and S.cerevisiae EBY100/pYD5-preS2/S(adr) for protecting and treating human against hepatitis B virus (HBV) infection, suggesting that yeast surface display expression system expressing HBsAg antigen has potential as a prophylactic treatment for HBV in human via oral vaccination. The technology developed in this patent application can also be used to produce edible (oral) vaccines for preventing and treating other infectious diseases in human.

机译：在此处描述的发明中，该方法是基于N端酵母表面展示表达平台配制可食用疫苗，该平台可产生啤酒酵母 EBY100 / pYD5-preS2 / S（adw）和酿酒酵母 EBY100 / pYD5-preS2 / S（adr）用于保护和治疗人类免受乙型肝炎病毒（HBV）感染，这表明表达HBsAg抗原的酵母表面展示表达系统具有潜在的预防性治疗作用。人类通过口服疫苗接种。该专利申请中开发的技术还可以用于生产可食用的（口服）疫苗，以预防和治疗人的其他传染病。 ~~展开▼~~

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公开/公告号US10793866B2

专利类型

公开/公告日2020-10-06

原文格式PDF

申请/专利权人 DOMINIC MAN-KIT LAM;OLIVIA YEE-YEE LAM;HAN LEI;
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申请/专利号US201815937622

发明设计人 DOMINIC MAN-KIT LAM;OLIVIA YEE-YEE LAM;HAN LEI;
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申请日2018-03-27

分类号A61K38;A61K39;C07K14;A61K38/16;A61K39/12;C12N15/81;G01N33/576;A61K39/29;A61K9/48;A61K9;

国家 US

入库时间 2022-08-21 11:28:33

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2. 修饰的人类U1snRNA分子、编码修饰的人类U1snRNA分子的基因、包括该基因的表达载体及其在基因治疗中的用途 [P] . 中国专利： CN103314106B . 2017.09.12

3. Edible vaccines expressed in yeast for preventing and treating infectious diseases, including Hepatitis B, in humans [P] . 美国专利： US2019300887A1 . 2019-10-03

机译：酵母中表达的可食用疫苗，用于预防和治疗人类的传染病，包括乙肝

4. Edible vaccines expressed in yeast for preventing and treating infectious diseases in animals and humans [P] . 美国专利： US10617751B2 . 2020-04-14

机译：酵母中表达的可食用疫苗，用于预防和治疗动物和人类的传染病

5. Edible vaccines expressed in yeast for preventing and treating infectious diseases in animals and humans. [P] . 美国专利： US2019298817A1 . 2019-10-03

机译：在酵母中表达的可食用疫苗，用于预防和治疗动物和人类的传染病。

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