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Polypeptide derivatives from grass carp interferon and application thereof
Polypeptide derivatives from grass carp interferon and application thereof
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机译:草鱼干扰素多肽衍生物及其应用
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摘要
Derivative polypeptide derived from a grass carp interferon and an application of the derivative polypeptide. An amino acid sequence of the derivative polypeptide is as shown in SEQ ID NO:1; the interferon-derived polypeptide has a high-efficiency antibacterial effect and can take effect against drug-resistant Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus agalactiae, Vibrio fluvialis or Aeromonas hydrophila. The interferon-derived polypeptide is less toxic to eukaryotes and can effectively reduce the mortality of mice in a mouse disease model caused by pathological bacteria. The interferon-derived polypeptide which is small in molecular weight is easily synthesized and has a good application value.
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机译:源自草鱼干扰素的衍生多肽及其应用。衍生多肽的氨基酸序列如SEQ ID NO:1所示;参见图1。干扰素来源的多肽具有高效的抗菌作用,并且可以对耐药性大肠杆菌,金黄色葡萄球菌,铜绿假单胞菌,无乳链球菌,河豚弧菌或嗜水气单胞菌 I>起作用。 >。干扰素来源的多肽对真核生物的毒性较小,并且可以有效降低在由病理细菌引起的小鼠疾病模型中的小鼠死亡率。分子量小的干扰素来源的多肽易于合成并且具有良好的应用价值。
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