首页>
外国专利>
Methods for engineering T cells for immunotherapy by using RNA-guided Cas nuclease system
Methods for engineering T cells for immunotherapy by using RNA-guided Cas nuclease system
展开▼
机译:利用RNA引导的Cas核酸酶系统工程改造T细胞以进行免疫治疗的方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention relates to methods of developing genetically engineered, preferably non-alloreactive T-cells for immunotherapy. This method involves the use of RNA-guided endonucleases, in particular Cas9/CRISPR system, to specifically target a selection of key genes in T-cells. The engineered T-cells are also intended to express chimeric antigen receptors (CAR) to redirect their immune activity towards malignant or infected cells. The invention opens the way to standard and affordable adoptive immunotherapy strategies using T-Cells for treating cancer and viral infections.
展开▼