USE AND METHOD OF L-ASPARTIC ACID beta-HYDROXAMATE IN PREPARING DRUGS FOR INHIBITING CHOROIDAL NEOVASCULARIZATION

摘要

A use and method of L-aspartic acid β-hydroxamate in preparing drugs for inhibiting choroidal neovascularization, achieving the effect of inhibiting the secretion of VEGF and MCP-1 by RPE which was induced with TNFα and thus inhibiting choroidal neovascularization, by injecting L-aspartic acid β-hydroxamate intravenously, and without severe side effects including retinal and choroidal atrophy, retinal detachment and intraocular infection induced by repeated intravitreal injections of anti-VEGF antibodies.