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METHODS FOR DIAGNOSING AND TREATING DISEASES BASED ON MODULATING DRUG EFFLUX BY BINDING TO CRYPTIC REGION OF CD44
METHODS FOR DIAGNOSING AND TREATING DISEASES BASED ON MODULATING DRUG EFFLUX BY BINDING TO CRYPTIC REGION OF CD44
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机译:结合CD44的隐秘区域调节药物外流的疾病诊断和治疗方法
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摘要
The present invention relates to methods for modulating efflux of drugs based on binding to a protein region of CD44 in part comprising the amino acid sequence specified in the provisional application referenced above, and incorporated in its entirety by reference herein (“PROV”). In some aspects, the present invention relates to methods for treatment of cancer by preventing the cellular efflux of therapeutic drugs; for example, preventing the cellular efflux of anti-cancer agents, for example a taxane, by contacting a CD44-modulating peptide, comprising the amino acid sequence specified in the provisional application referenced above, and incorporated in its entirety by reference herein (“PROV”).
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