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ANTIGEN BINDING FRAGMENTS CONJUGATED TO A PLURALITY OF FC ISOTYPES AND SUBCLASSES
ANTIGEN BINDING FRAGMENTS CONJUGATED TO A PLURALITY OF FC ISOTYPES AND SUBCLASSES
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机译:与多种FC同种型和亚类结合的抗原结合片段
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摘要
The invention pertains to a plurality of full-length antibodies, wherein each full-length antibody comprises an antigen binding fragment specifically binding to a unique antigen and comprises a first binding motif at the C-terminus and an Fc fragment belonging to a unique combination of species, isotype and subclass and comprises a second binding motif at the N-terminus, wherein the first binding motif and the second binding motif for each antibody are covalently conjugated to each other via protein ligation. Assays for detecting a plurality of antigens in a sample by contacting the sample with the plurality of full-length antibodies are also provided. Further provided are nucleic acid constructs encoding the plurality of full-length antibodies.
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