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METHODS FOR SCAR REDUCTION BY CONVERTING SCAR FIBROBLASTS INTO ADIPOCYTES WITH HAIR FOLLICLE-DERIVED SIGNALS
METHODS FOR SCAR REDUCTION BY CONVERTING SCAR FIBROBLASTS INTO ADIPOCYTES WITH HAIR FOLLICLE-DERIVED SIGNALS
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机译:通过将瘢痕成纤维细胞转化为具有毛发源性信号的脂肪细胞来减少瘢痕的方法
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摘要
This invention describes methods for treating wound healing pathologies, inhibiting or reversing fibrotic skin disorders, including but not limited to keloids, atrophic and hypertrophic scars, and reversing skin aging via generating new dermal adipocytes (DAs). Methods described herein comprise (a) grafting of human hair follicles or (b) direct delivery of conditioned media from in vitro cultured hair follicles, or (c) delivery of purified individual factors secreted by hair follicles, or (d) delivery of small molecule agonists that mimic hair derived signaling activities, or (e) delivery of small molecule antagonists that inhibit anti-adipogenic programs, or (f) delivery of small molecule agonists of pro-adipogenic programs to convert endogenous wound or scar skin fibroblasts into new DAs.
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