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PEPTIDES HAVING OSTEOBLAST GROWTH-PROMOTING ACTIVITY AND USE THEREOF

机译：具有促进成骨细胞生长活性的肽及其用途

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摘要

The present invention provides a novel peptide having bone formation-promoting effect and chondrocyte growth-promoting effect, in particular, a peptide having osteoblast growth-promoting activity, having 100 amino acid residues or less comprising an amino acid sequence selected from; <TableGroup align="left" colSep="0" cols="1" rowSep="0"> <Colspec align="left" colName="1" colWidth="217pt"/> <Tbody valign="top"> <Row> <entry>(a)</entry> </Row> <Row> <entry>(SEQ ID NO: 1)</entry> </Row> <Row> <entry>Val-Asn-Pro-Glu-Ser-Glu-Glu-Glu-Asp-Glu-Ser-Ser-</entry> </Row> <Row> <entry>Pro-Tyr-Glu,</entry> </Row> </Tbody> </TableGroup> </TableFormula> </Table> <UnorderedList id="ul0001" listStyle="none"> <ListItem id="ul0001-0001" number="0000"> <UnorderedList id="ul0002" listStyle="none"> <ListItem id="ul0002-0001" number="0000">(b) an amino acid sequence derived from the amino acid sequence (a) by conservative substitution or deletion of 1 to 3 amino acids, and</ListItem> <ListItem id="ul0002-0002" number="0000">(c) an amino acid sequence consisting of at least four contiguous amino acids of the amino acid sequence (a) or (b), or</ListItem> <ListItem id="ul0002-0003" number="0000">a derivative thereof or a salt thereof.</ListItem> </UnorderedList> </ListItem> </UnorderedList> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span>本发明提供了具有骨形成促进作用和软骨细胞生长促进作用的新型肽，特别是具有100个以下的氨基酸残基的选自以下的氨基酸序列的具有成骨细胞生长促进作用的肽。 <Table id =“ TABLE-US-00001”> <TableFormula> <标题/> <TableGroup align =“ left” colSep =“ 0” cols =“ 1” rowSep =“ 0”> <Colspec align =“ left” colName =“ 1” colWidth =“ 217pt” /> <Tbody valign =“ top”> <行> <entry>（a）</ entry> </ Row> <行> <entry>（SEQ ID NO：1）</ entry> </ Row> <行> <entry> Val-Asn-Pro-Glu-Ser-Glu-Glu-Glu-Asp-Glu-Ser-Ser-</ entry> </ Row> <行> <entry> Pro-Tyr-Glu </ entry> </ Row> </ Tbody> </ TableGroup> </ TableFormula> </ Table> <UnorderedList id =“ ul0001” listStyle =“ none”> <ListItem id =“ ul0001-0001” number =“ 0000”> <UnorderedList id =“ ul0002” listStyle =“ none”> <ListItem id =“ ul0002-0001” number =“ 0000”>（b）通过保守取代或缺失1至3个氨基酸而衍生自氨基酸序列（a）的氨基酸序列，以及</ ListItem> <ListItem id =“ ul0002-0002” number =“ 0000”>（c）由氨基酸序列（a）或（b）的至少四个连续氨基酸组成的氨基酸序列，或</ ListItem> <ListItem id =“ ul0002-0003” number =“ 0000”>其衍生物或其盐。</ ListItem> </ UnorderedList> </ ListItem> </ UnorderedList> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33">著录项</h2> <div class="getdents"> <ul> <li> <p><span>公开/公告号</span><span>US2020157165A1</span></p> <p><span>专利类型</span><span></span></p> </li> <li> <p><span>公开/公告日</span><span>2020-05-21</span></p> <p><span>原文格式</span><span>PDF</span></p> </li> <li> <div class="apply"> <p><span style="width: 90px;display: inline-block;">申请/专利权人</span><span id="patentee" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=12_13&sertext=PHARMA FOODS INTERNATIONAL CO. LTD.&option=232">PHARMA FOODS INTERNATIONAL CO. LTD.;</a> </span></p> <span class="designer hoverxs" style="display: none;">展开▼</span> </div> <p><span>申请/专利号</span><span style="width: 250px;">US201916703177</span></p> </li> <li> <div class="apply"> <p><span style="width: 90px;display: inline-block;">发明设计人</span><span id="patentee" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=12_13&sertext=CHIHIRO YAMAZAKI&option=202">CHIHIRO YAMAZAKI;</a><a href="/search.html?doctypes=12_13&sertext=JI-YEONG AN&option=202">JI-YEONG AN;</a><a href="/search.html?doctypes=12_13&sertext=SEIYU HARADA&option=202">SEIYU HARADA;</a><a href="/search.html?doctypes=12_13&sertext=KAZUYA WATABE&option=202">KAZUYA WATABE;</a><a href="/search.html?doctypes=12_13&sertext=MUJO KIM&option=202">MUJO KIM;</a> </span></p> <span class="designer hoverxs" style="display: none;">展开▼</span> </div> <p><span>申请日</span><span>2019-12-04</span></p> </li> <li> <p style="width: 100%;"><span>分类号</span><span style="width: 80%;">C07K14/51;A23L33/18;A61K8/64;A61Q19;A61K38/04;C07K7/08;C07K7/06;A61K38/10;C07K7/04;A61K38/08;</span> </p> </li> <li> <p style="width: 100%;"><span>国家 </span><span style="width: 93%;">US</span></p> </li> <li><p style="width: 100%;"> <span >入库时间</span> <span>2022-08-21 11:23:41</span></p> </li> </ul> </div> </div> </div> <div class="literature cardcommon"> <div class="similarity"> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul > <li >专利</li> <li >外文文献</li> <li >中文文献</li> </ul> </div> <div class="similarity_details"> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/061203264577.html">一种具有促进成骨细胞增殖活性的乳铁蛋白肽的制备方法</a> <b>[P]</b> . <span> 中国专利： CN105177097B </span> <span> . 2019.04.09</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120108536271.html">具有成骨细胞增殖促进活性的肽及其利用</a> <b>[P]</b> . <span> 中国专利： CN106029685A </span> <span> . 2016-10-12</span> </div> </li> 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