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PEPTIDES HAVING OSTEOBLAST GROWTH-PROMOTING ACTIVITY AND USE THEREOF
PEPTIDES HAVING OSTEOBLAST GROWTH-PROMOTING ACTIVITY AND USE THEREOF
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机译:具有促进成骨细胞生长活性的肽及其用途
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摘要
The present invention provides a novel peptide having bone formation-promoting effect and chondrocyte growth-promoting effect, in particular, a peptide having osteoblast growth-promoting activity, having 100 amino acid residues or less comprising an amino acid sequence selected from;(a) Val-Asn-Pro-Glu-Ser-Glu-Glu-Glu-Asp-Glu-Ser-Ser-Pro-Tyr-Glu (SEQ ID NO: 1),(b) an amino acid sequence derived from the amino acid sequence (a) by conservative substitution or deletion of 1 to 3 amino acids, and(c) an amino acid sequence consisting of at least four contiguous amino acids of the amino acid sequence (a) or (b), ora derivative thereof or a salt thereof.
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机译:本发明提供了具有骨形成促进作用和软骨细胞生长促进作用的新型肽,特别是具有选自以下的氨基酸序列的100个以下的氨基酸残基的具有成骨细胞生长促进作用的肽。 Val-Asn-Pro-Glu-Ser-Glu-Glu-Glu-Asp-Glu-Ser-Ser-Pro-Tyr-Glu(SEQ ID NO:1),(b)通过保守取代或缺失1至3个氨基酸而衍生自氨基酸序列(a)的氨基酸序列,和(c)由氨基酸序列(a)或(b)的至少四个连续氨基酸组成的氨基酸序列,或其衍生物或其盐。
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