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A PAIR OF AMINO ACID SEQUENCES FOR MONITORING FORMATION OF TDP-43 OLIGOMER IN LIVING CELLS VIA BIMOLECULAR FLUORESCENCE COMPLEMENTATION
A PAIR OF AMINO ACID SEQUENCES FOR MONITORING FORMATION OF TDP-43 OLIGOMER IN LIVING CELLS VIA BIMOLECULAR FLUORESCENCE COMPLEMENTATION
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机译:一对氨基酸序列,通过双分子荧光互补监测活细胞中TDP-43寡聚体的形成
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摘要
The present disclosure relates to a vector pair for screening TDP-43 (TAR DNA-binding protein 43 or TransActive Response DNA-binding protein 43) oligomer formation, a cell line transfected with the vector pair, and a method of monitoring TDP-43 oligomer formation using the cell line. More specifically, the vector pair includes: a first vector including a first TDP-43 gene and a first fluorescence protein gene; and a second vector including a second TDP-43 gene and a second fluorescence protein gene, wherein a protein expressed from the first fluorescence protein gene and a protein expressed from the second fluorescence protein gene bind to each other to display fluorescence, by association between a protein expressed from the first TDP-43 gene and a protein expressed from the second TDP-43 gene. The vector pair is effective in that it makes it possible to monitor TDP-43 oligomer formation in living cells.
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