Disclosed herein are biosensors for sensing analyte concentration values, and methods of operating such sensors. The biosensor includes a probe. The probe includes a base substrate and a plurality of electrode sets overlying the base substrate. Each set of the plurality of electrode sets being individually operable for measuring a glucose concentration value when the probe is implanted in a patient. The probe also includes a biodegradable coating covering at least one electrode set of the plurality of electrode sets. The biodegradable coating does not cover at least one other electrode set of the plurality of the electrode sets.
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