A biosensor for sensing analyte concentration values includes a probe comprising a base substrate and a plurality of electrode sets overlying the base substrate. Each set of the plurality of electrode sets is individually operable for measuring a glucose concentration value when the probe is implanted in a patient. The probe also includes a biodegradable coating covering at least one electrode set of the plurality of electrode sets. The biodegradable coating does not cover at least one other electrode set of the plurality of the electrode sets. The thickness of the biodegradable coating is selected such that the time taken for the coating to fully degrade corresponds to the time taken for the first electrode set to become inoperative or inaccurate due to biofouling. Degradation of the coating may also be initiated using an electrical or heat impulse generator. After full degradation of the coating, the second electrode set is then exposed to the blood and interstitial fluid of the user and may then be used in the monitoring of glucose concentration levels of the user.
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