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ENGINEERED DNASE ENZYMES AND USE IN THERAPY
ENGINEERED DNASE ENZYMES AND USE IN THERAPY
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机译:工程化DNASE酶及其在治疗中的用途
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摘要
The present invention provides engineered DNase proteins (including DNase1-like 3 and DNase1) that are useful for treating conditions characterized by neutrophil extracellular trap (NET) accumulation and/or release. In some aspects, the invention provides compositions and methods for preventing or treating vascular occlusion involving NETs. As demonstrated herein, NETs participate in a non-canonical mechanism for vascular occlusion, which is not dependent on fibrin or platelets.
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