engineered DNase enzymes and use in therapy

摘要

the present invention provides engineered dnase proteins (including dnase1 type 3 and dnase1) that are useful in the treatment of conditions characterized by accumulation and / or release of extracellular neutrophil trap (net). in some respects, the invention provides compositions and methods for preventing or treating vascular occlusion involving nets. as demonstrated in this document, nets participate in a non-canonical mechanism of vascular occlusion, which does not depend on fibrin or platelets.