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PHARMACOLOGICAL RESTORATION OF EPITHELIAL OR ENDOTHELIAL BARRIER INTEGRITY BY AGENTS BLOCKING EPAC/RAP1 SIGNALING
PHARMACOLOGICAL RESTORATION OF EPITHELIAL OR ENDOTHELIAL BARRIER INTEGRITY BY AGENTS BLOCKING EPAC/RAP1 SIGNALING
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机译:通过阻止EPAC / RAP1信号传导的药物修复上皮或内皮屏障的完整性
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摘要
Methods and pharmaceutical compositions for treating diseases characterized by compromised epithelial or endothelial barrier integrity are provided. The pharmaceutical compositions include an effective amount a Epac/Rap1 signaling inhibitor. The methods include administering to a patient suffering from a disease characterized by compromised epithelial or endothelial barrier integrity a therapeutically effective amount of a Epac/Rap1 signaling inhibitor, such as ESI-09, SecinH3, Slit, or AG1024.
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