首页> 外国专利> Composition For Preventing Or Treating TNF-Related Diseases, Containing Novel Derivative As Active Ingredient, And Method For Inhibiting TNF Activity By Using Same

Composition For Preventing Or Treating TNF-Related Diseases, Containing Novel Derivative As Active Ingredient, And Method For Inhibiting TNF Activity By Using Same

机译:以新型衍生物为有效成分的预防或治疗TNF相关疾病的组合物,以及使用该组合物抑制TNF活性的方法

摘要

The present invention relates to: a 4-benzopyranone derivative and a pharmaceutically acceptable salt, solvate, racemate, or stereoisomer thereof; a composition for preventing, alleviating or treating TNF-related diseases, containing the same as an active ingredient; and a method for treating TNF-related diseases, a reagent composition for inhibiting TNF, and a method for inhibiting TNF, all of which use the same. The compositions can be orally administered so as not to cause injection side effects, do not cause immunological tolerance, and can effectively inhibit a TNF activity by being directly bound to TNF while facilitating co-administering with a conventional oral preparation and dosage control.
机译:本发明涉及:4-苯并吡喃酮衍生物及其药学上可接受的盐,溶剂化物,外消旋物或立体异构体。用于预防,减轻或治疗TNF相关疾病的组合物,含有该组合物作为活性成分;以及使用它们的治疗TNF相关疾病的方法,抑制TNF的试剂组合物和抑制TNF的方法。可以口服施用该组合物,以不引起注射副作用,不引起免疫耐受,并且可以通过直接与TNF结合而有效地抑制TNF活性,同时促进与常规口服制剂和剂量控制的共同施用。

著录项

  • 公开/公告号US2020246304A1

    专利类型

  • 公开/公告日2020-08-06

    原文格式PDF

  • 申请/专利权人 ILAB;

    申请/专利号US201816757112

  • 发明设计人 TAE-HWE HEO;KYE JUNG SHIN;

    申请日2018-07-12

  • 分类号A61K31/352;C07D311/30;A61K45/06;A61K9;

  • 国家 US

  • 入库时间 2022-08-21 11:21:04

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