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ACPA-NEGATIVE RA DIAGNOSTIC MARKER AND APPLICATION THEREOF
ACPA-NEGATIVE RA DIAGNOSTIC MARKER AND APPLICATION THEREOF
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机译:ACPA阴性RA诊断标记及其应用
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摘要
The invention provides a use of a deoxyhypusine dioxygenase DOHH or a fragment thereof in the preparation of a reagent for diagnosing an anti-citrulline polypeptide antibody-negative rheumatoid arthritis disease. 35 proteins as candidate ACPA-negative RA autoantigens were screened by hybridizing high density protein chips with RA serum. 4 protein antigens (DOHH, DUSP11, PTX3 and PAGE5) were identified as having high sensitivity and specificity in the ACPA-negative serum of RA, wherein DOHH can be used as the ACPA-negative RA diagnostic markers.
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