recombinant viral capsid protein, recombinant viral capsid, vector and recombinant viral particle, composition, methods of delivering a nucleotide of interest to a target cell, providing a viral capsid protein and producing a viral particle, viral particle, packaging cell and recombinant vector

摘要

in this document, compositions and methods are provided for the redirection of recombinant viral capsid particles through a specific protein: protein binding pair that form a covalent bond, for example isopeptide, to display a targeting ligand in the capsid protein, in that the targeting ligand specifically binds to a cell surface marker expressed on the cell of interest.