compound, method for testing the ability of one or more compounds, method for inhibiting ras function, method for inhibiting rho function, method for inhibiting rac function, pharmaceutical composition

摘要

the present invention relates to methods and compositions for treating cancers, inflammatory diseases, rasopathies and fibrotic diseases that involve abnormal signaling of the superfamily by binding compounds to the gtp-binding domain of ras superfamily proteins, including, in certain cases , k-ras and mutants thereof, and an innovative method for evaluating such compositions.