use of recombinant von willebrand factor (rvwf)

摘要

the present invention relates to a method for pretreating a subject with severe von willebrand disease prior to a surgical procedure comprising administering to the subject a dose ranging from about 20 iu / kg to about 60 iu / kg of rvwf between about 12 hours and about 24 hours before the surgical procedure, and in which factor viii is not administered with the rvwf before the surgical procedure.