composition of matter, fusion protein, pharmaceutical composition, method of treatment or prevention of a disease or viral infection associated with arenavirus in an individual in respective need, isolated polynucleotide, nucleic acid structure, method of producing a polypeptide and method of diagnosis of an arenavirus viral infection in an individual

摘要

composition of matter, fusion protein, pharmaceutical composition, method of treatment or prevention of a disease or viral infection associated with arenavirus in an individual in respective need, isolated polynucleotide, nucleic acid structure, method of producing a polypeptide and method of diagnosis of an arenavirus viral infection in an individual. discloses a composition of matter, comprising an isolated soluble polypeptide comprising an amino acid sequence of an apical domain of the transferrin receptor protein 1 (tfr1), the soluble polypeptide being able to bind to an arenavirus. a fusion protein is also disclosed, comprising an amino acid sequence from an apical domain of tfr1 and an amino acid sequence from igg fc, the fusion protein capable of binding to an arenavirus.