purified polypeptide, topical formulation, isolated polynucleotide, vector, recombinant microorganism, topical probiotic composition, drug composition, and, methods of treating a dermatological disorder, treating a skin disease or disorder, and delivering drugs through the skin.

摘要

the invention provides a purified polypeptide that inhibits (i) protease production and / or keratinocyte activity, (ii) inhibits il-6 production and / or keratinocyte activity, (iii) inhibits phenol modulin production soluble alpha 3 of staphylococcus aureus and / or (iv) inhibits agr production and / or activity per second. aureus. a topical formulation comprising the polypeptide is additionally provided. a recombinant microorganism is provided which comprises a vector or polynucleotide that encodes the polypeptide. additionally a probiotic composition is provided which comprises the recombinant microorganism. the invention also provides kits and articles of manufacture comprising the polypeptide and / or the recombinant microorganism.