naphthalene carboxamide derivatives as protein kinase and histone deacetylase inhibitors, preparation methods and uses

摘要

naphthalene carboxamide derivatives as protein kinase and histone deacetylase inhibitors, preparation methods and uses are provided naphthalene carboxamide derivatives, methods of preparation and uses thereof. their structure is shown as formula (1), when the definitions of r1, r, r3, d4 and z are the same as described in the description. the compounds have protein kinase inhibiting activities and histone deacetylase inhibiting activities simultaneously, and can be used to treat diseases associated with abnormal protein kinase activity or abnormal histone deacetylase activity, including inflammation, autoimmune diseases, cancer, cancer diseases nervous system and neurodegenerative diseases, cardiovascular diseases and metabolic diseases, allergic asthma and hormone-related diseases. (fig. 1)