recombinant human alpha-1 antitrypsin (rhaat), and method for producing recombinant human alpha-1 antitrypsin (rhaat), and use thereof. the present invention relates to recombinant human (alpha) -1 antitrypsin (rhaat) comprising n-linked glycans, wherein at least 10% of said n-linked glycans are tetra antennary glycans; and the degree of coating with sialic acid in said glycans attached to n (z / a) is at least 50%. the invention further relates to rhaat for use as a medicament, in particular for use in preventing and / or treating a disease associated with aat deficiency and / or a disease involving neutrophil-mediated tissue damage.
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