Anti human antibody and its application （Divisional request 201802925）.

摘要

26lt p 26gt (57) Abstroct The iuvcntiou providcs autagonistic and agonistic nnli -humru1 VISTA llltiboctie aud autibody fragmcnts Thcsc ant - 26lt br 2F 26gtagorlist ullibodies and autibody f ragmcuts may be used to inh ibit or block VISTA 26amp 2339 s suppressive efTects on T cell iuununity aud 3D lhe reby promote T ceU inmtunity These agor 26amp uacute st auJiboctics and antibody fragrnerns may be used to potentiate or euhancc or mimic V ST A 26amp 2339 s suppress ivc effects on T ccll immunity ancl therehy wppress T cell immunity Thcso antagonist antibodies and antibody O frugmcuts are especially useful in the treannent of canc 26amp lt r and infcclious conditions These agonist antibodies and antibody fragments 26amp gt rife cspecially 26amp iexcl 26amp iexcl Scrcening a says for identit) 26amp 2339 iug these agonists a re also providcd 26lt 2Fp 26gt