COOPERATIVE MARKETING AUTHORISATION HOLDER

摘要

This invention concerns a method of treatment of MS in a human patient who needs such treatment and includes the administration of a combination therapy to that patient. treatment ina single form of oral dosing (e. g. a foil dimethyl ester tablet or capsule and a factor selected from terflumide (or its prophylactic leflunomide)Fingolimode and laryngitis. This combination is more effective than the factors alone and/or has reducedeffects and better tolerance than the factors alone and/or may be administered with a reduced frequency. AdditionallyThis invention concerns a pharmaceutical formulation suitable for the oral treatment of laminated sclerosis consisting of a fumarate dimethyl ester and a factor selected from terflumide,Fingolimode and glucinomide as active ingredients and one or more medically acceptable excipients.