PRINCIPLES ISSUING A LIMITED FREE FISHERIES RESTORY

摘要

A genetically modified mouse is provided,where the mouse expresses a repertoire of light immunoglobulin chains characterised by a limited number of variable areas.chain saw. There are mice presenting a selection of two human genetic parts of a variable light chain areaso that the light chains of immunoglobulin expressed by the mouse include one of the two human genetic parts of a varying range of elevenchain root. Methods are provided for the formation of bisexual antibodies having universal light chains using mice described in thisincluding human variable light chain areas. Methods are provided for the creation of human variable areas suitable for use in multispecific binding proteins,e.g. Amphibial antibodies,and host cells.