REDUCING VIRULENCE OF BACTERIA BY DECREASING FOLAT TRANSPORT IN BACTERIA

摘要

The present invention relates to bacterial infections, vaccines against these infections and bacterial vaccines. More specifically, the present invention relates to vaccines directed against streptococcal infections in pigs. The present invention provides a ∆FolT mutant of a bacterium having a reduced ability to transport folate, said ability being reduced by functional removal of the folate transporter function (FolT). The present invention also provides a method for reducing virulence of a bacterium, comprising reducing the ability of said bacterium to transport folate.