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Macrocyclization reactions and intermediates and other fragments useful in the synthesis of halichondrin macrolides
Macrocyclization reactions and intermediates and other fragments useful in the synthesis of halichondrin macrolides
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机译:大环化反应,中间体和其他片段可用于合成蛇绿素大环内酯
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摘要
The invention provides methods for the synthesis of a halichondrin macrolides through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Horner-Wadsworth-Emmons olefination), catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.
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