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Lipid formulations for delivery of messenger rna
Lipid formulations for delivery of messenger rna
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机译:用于递送信使RNA的脂质制剂
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摘要
The present invention provides, among other things, methods of delivering mRNA in vivo, including administering to a subject in need of delivery a composition comprising an mRNA encoding a protein, encapsulated within a liposome such that the administering of the composition results in the expression of the protein encoded by the mRNA in vivo, wherein the liposome comprises a cationic lipid of formula I-c: or a pharmaceutically acceptable salt thereof.
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