Indirect biomarker to evaluate the accumulation of intracerebral beta amyloid peptide and method for its analysis

摘要

An analytical method for determining a brain Aβ accumulation state, the method of which comprises: a measurement step in which a sample obtained from a living body obtained from a test subject is subjected to detection of a marker containing: APP672 -713 (Aβ1-42) (SEQ ID NO .: 6) and APP669-711 (SEQ ID NO .: 7), to obtain measurement levels of: APP672-713 (Aβ1-42) and APP669-711 in the sample obtained from a living body; a calculation step in which a ratio of the level of APP669-711 to the level of APP672-713 (Aβ1-42) or APP669-711 / APP672-713 (Aβ1-42) is calculated; and an evaluation step in which it is determined that a brain Aβ accumulation amount of the test subject is greater than a brain Aβ accumulation amount of a person having normal NC- cognitive function, which is negative for accumulation. of brain Aβ, when the test subject's ratio is higher than a standard level, which is a ratio of the person having normal NC- cognitive function.