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USE OF OLIGOSACCHARIDE COMPOUNDS FOR THE PREVENTION AND TREATMENT OF PATHOLOGICAL SCARS

机译:使用寡糖化合物预防和治疗病理性瘢痕

摘要

The subject of the present invention is a compound chosen from synthetic polysulfated oligosaccharides having 1 to 4 ose units, their salts or their complexes, for its use for treating wounds generating pathological scars chosen from hypertrophic, retractable scars or even atrophic scars . This application is particularly preferred in subjects with a predisposition to the development of hypertrophic, retractile or atrophic scars. A subject of the invention is also, according to a second aspect, said compound for its use for inhibiting the differentiation of fibroblasts into myofibroblasts during the healing of wounds generating pathological scars chosen from hypertrophic, retractile or atrophic scars.
机译:本发明的主题是选自具有1-4个糖单位的合成多硫酸化低聚糖的化合物,其盐或它们的络合物,其用于治疗产生病理性瘢痕的伤口的用途,所述病理性瘢痕选自肥厚性,可伸缩性疤痕或萎缩性疤痕。对于有肥厚性,可回缩性或萎缩性疤痕易感性的个体,该应用特别优选。根据第二方面,本发明的主题还在于所述化合物,其用于在伤口愈合期间抑制成纤维细胞分化为成肌纤维细胞的用途,所述伤口产生选自增生性,可回缩性或萎缩性瘢痕的病理性瘢痕。

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