ORAL CARE COMPOSITION BASED ON CALCIUM PHOSPHATE POLYIONIC CLUSTERS

摘要

An oral care composition is disclosed comprising: a) calcium phosphate polyionic clusters; b) glycerin; wherein the calcium phosphate polyionic clusters are obtained by a process comprising the steps of: i) dissolving a water soluble calcium source in ethanol to produce an ethanol solution A having a calcium ion concentration from 5 to 60 mmol/L; ii) dissolving phosphoric acid and triethylamine in ethanol to produce an ethanol solution B having a phosphoric acid concentration from 10 to 120 mmol/L and a triethylamine concentration from 1000 to 3900 mmol/L; iii) mixing the solution A and the solution B and standing the mixture to obtain a calcium phosphate polyionic cluster solution; iv) centrifuging the calcium phosphate polyionic cluster solution to obtain calcium phosphate polyionic clusters, wherein the water soluble calcium source is a calcium source that dissolves in water to give a concentration of at least 0.1 moles per litre at 25°C and atmospheric pressure.